Wasp Venom Study Leads To New Breast Cancer Therapy Design

Wasp Venom Study Leads To New Breast Cancer Therapy Design
wasp venom breast cancerResearchers from the Institute for Biomedical Research (IRB Barcelona) have successfully managed to induce breast tumor cell death in vitro using wasp venom. In this study, entitled "Delivering wasp venom for cancer therapy" and published in the Journal of Controlled Release, the team designed a new therapy based on a cytotoxic peptide, Mitroparan, derived from wasp venom and conjugated to a poly(l-glutamic acid) polymer containing specific tumor protease cleavage sequences such as metalloproteinase-2 (MMP-2) or cathepsin B. Once the peptide is released through the tumor proteases, it becomes active inducing the apoptosis (cell death) of tumor cells. "This peptide has the ability to form pores in the cell plasma membrane, penetrate into the cell and finally, cause its death, either by necrosis or by triggering apoptosis, programmed cell death," Miguel Moreno, a researcher at IRB Barcelona and lead author of the study, explained to Plataforma Sinc. Multiple cytolytic peptides have emerged in the last 30 years, however, due to their nonspecific cytolitic activity alongside rapid degradation, their use has been severely compromised, despite the potential therapeutic properties. Mitr
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