Soy Supplements May Affect Breast-Cancer Genes, According to Study

Soy Supplements May Affect Breast-Cancer Genes, According to Study
Soy Supplements and breast cancerIn a recent study entitled “The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study published in the Journal of the National Cancer Institute (JNCI), researchers concluded that consuming soy protein supplements could lead to adverse genetic changes for women with breast cancer. The team analyzed 140 women diagnosed with invasive breast cancer that either took soy protein powder or a placebo control between 7 and 30 days before undergoing cancer surgery. Plasma isoflavones (genistein and daidzein) were determined, and tumor tissue before and after surgery was compared to observe changes in the expression of genes involved in cell growth. The results indicated that among the soy group, plasma isoflavones rose and 21 genes (out of 202 analyzed) had altered expression. A high-genistein signature consisting of 126 differentially expressed genes was identified from microarray analysis of tumors and characterized by overexpression of cell cycle transcripts, including those promoting cell proliferation. "We do not know what the consequences of taking soy for longer periods or taking higher amounts of soy, would have on the biology of a breast tumor," Dr. Jackie Brom
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