New, More Useful Way to Study Immortalized Mammary Cells Developed at Berkeley Laboratory

New, More Useful Way to Study Immortalized Mammary Cells Developed at Berkeley Laboratory
shutterstock_90051502Dr. Martha R. Stampfer's laboratory at Lawrence Berkeley National Laboratory took a new approach to generating immortalized human mammary epithelial cells and now has "a very good model of a critical step in cancer progression," according to her colleague, Dr. James C. Garbe. The two were on a team at Berkeley trying to develop a more useful model of early cancer progression that could be used as a platform to explore therapeutics directed against tumor development. "We believe that research on these cells may stimulate new approaches for therapeutic intervention in cancer progression at the earliest stages," said Dr. Garbe in a news release from Berkeley. The team's findings regarding this approach were published as "Immortalization of Normal Human Mammary Epithelial Cells in Two Steps by Direct Targeting of Senescence Barriers Does Not Require Gross Genomic Alterations" in the journal Cell Cycle. Most models of immortalized human cells rely upon genetic alterations to induce immortality. The altered genome can confound underlying reasons for cancer progression and mask errors responsible for immortalization due to overshad
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