Study Compares Breast Cancer Recurrence Over Time

Study Compares Breast Cancer Recurrence Over Time
shutterstock_224671834In a recent publication titled Comparison of Breast Cancer Recurrence and Outcome Patterns Between Patients Treated From 1986 to 1992 and From 2004 to 2008, published in the Journal of Clinical Oncology, a team of researchers from the Vancouver Cancer Centre, designed a study to determine if the patterns of relapse in breast cancer, considering the estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) phenotype, have been altered throughout time. As such, the research team analyzed data from women registered in the British Columbia Cancer Agency who had undergone biopsies to diagnose stage I to III breast cancer between the time period of 1986 and 1992 (cohort 1 [C1]) and 2004 and 2008 (cohort 2 [C2]). Furthermore, these patients’ ER and HER2 status were known. After all data were gathered, the team grouped a total of 7,178 C1 and C2 patients according to cancer stage, grade, and ER and HER2 phenotype. The main outcomes of this study included hazard rate of relapse (HRR) for breast cancer according to biomarker status, stage, grade, and age, along with hazard rate of death (HRD). The results showed that among all patients, 70.8% were ER positive/HER2 negative, 6.9% were ER positiv
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