Researchers Find Protein Involved In Breast Cancer Metastasis

Researchers Find Protein Involved In Breast Cancer Metastasis
shutterstock_117502462In several types of cancers, there is normally the expression of prototypic chitinase-like proteins, usually reflecting a poor prognosis even though its relevance for cancer progression is unknown. In a new study entitled “Role of Chitinase 3-like-1 and Semaphorin 7A in Pulmonary Melanoma Metastasis”, published in Cancer Research, a team of researchers from Brown University have found that increased serum levels of chitinase 3-Like-1 (CHI3L1) protein are associated with disease severity, poorer prognosis, and decreased survival in many human neoplasias, including breast cancer. Chitinase 3-Like-1 (CHI3L1) protein, also called YKL-40, is a secreted 40 kDa glycoprotein that is upregulated in a number of human cancers and in non-neoplastic disease states characterized by chronic inflammation and tissue remodeling. "We think everybody has Chitinase 3-like-1 (CHI3L1) in them because it plays a major role in our ability to fight off infections," study author Dr. Jack A. Elias, dean of medicine and biological sciences at Brown University, said in a 
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