Antiepilepsy Drug Reduces Metastasis in Breast Cancer Animal Model

Antiepilepsy Drug Reduces Metastasis in Breast Cancer Animal Model
breast cancer biomarkerPhenytoin, a drug that blocks sodium channels on the membranes of cells, may have implications on breast cancer cells. Previously, phenytoin was only used as a drug to treat epilepsy, but researchers in the Department of Biology at University of York are finding ways it can battle breast cancer cells. "This is the first study to show that phenytoin reduces both the growth and spread of breast cancer tumour cells," said Dr. Will Brackenbury, lead investigator on the study, in a news release. "This indicates that re-purposing antiepileptic and antiarrhyrthmic drugs is worthy of further study as a potentially novel anti-cancer therapy." Published in Molecular Cancer, the team's study, "The Sodium Channel-blocking Antiepileptic Drug Phenytoin Inhibits Breast Tumour Growth and Metastasis," investigated the effects of phenytoin on metastatic MDA-MB-231 breast cancer cells grown in vivo with the interest of decreasing cell growth and metastasis. The team chose phenytoin as a modulator of breast cancer cell activity because some tumor cell types, including
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