Researchers Suggest New Therapy for BRCA-Related Tumors

Researchers Suggest New Therapy for BRCA-Related Tumors
telomeresResearchers at NYU Langone Medical Center recently revealed a new approach to delay the growth of BRCA-related cancers. The study, entitled “Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination,” was published in the prestigious journal Nature. BRCA1 and BRCA2 genes are known to produce tumor suppressor proteins that help repair damaged DNA, ensuring the integrity of the genetic material. When one or both of these genes suffers mutations, their encoding protein may no longer be produced or have its function compromised, potentially resulting in a defective DNA repair mechanism and increased risk for genetic alterations that may lead to cancer. It is well-known that if a woman inherits specific mutations in the BRCA1 or BRCA2 genes, her risk for developing breast and/or ovarian cancer is greatly increased. Researchers found that by blocking the activity of a specific enzyme — polymerase theta, also known as PolQ – it was possible to drastically slow the development of cancer cells linked to BRCA1 and BRCA2
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