Breast Cancer May be Treated by Targeting Blood Vessels

Breast Cancer May be Treated by Targeting Blood Vessels
A study led by Valerie LeBleu of The University of Texas MD Anderson Cancer Center demonstrated the therapeutic potential of targeting both pericytes in blood vessels and a vascular growth factor, called Angiopoietin-2 (ANG2). The study entitled “Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2” was published in Cell Reports on February 24, 2015. Tumor progression is associated with new blood vessel formation grown from pre-existing ones, a process Valerie LeBleuknown as angiogenesis. This provides cancer cells with oxygen, nutrients and a route to spread to other tissues in the body. Pericytes are cells that wrap around blood vessels, stabilizing vasculature. Its depletion has been regarded as a strategy to prevent blood supply to the tumor. In this study, the research team found that in advanced stages of breast cancer, although depletion of pericytes decreases tumor growth, it increases lung metastasis through leaky vasculature. This effect is accompanied by enhanced production of ANG2 that further destabilizes normal vasculature. When pericyte depletion was combined with ANG2 antibody inhibition, both tumor growth and metastatic disease was re
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.