Women Diagnosed With Aytpia or DCIS After Breast Cancer Biopsy Should Get Second Opinion

Women Diagnosed With Aytpia or DCIS After Breast Cancer Biopsy Should Get Second Opinion
86055_webAccording to a recent study published in JAMA, even though clinicians usually agree on a pathology diagnosis, this consensus can still improve upon biopsy results of atypia diagnoses (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ). In the study entitled "Diagnostic Concordance Among Pathologists Interpreting Breast Biopsy Specimens,"  Tracy Onega, PhD and Anna Tosteson, ScD working at Dartmouth-Hitchcock Norris Cotton Cancer Center, assessed the proportion of overinterpreted and underinterpreted diagnoses relative to consensus-derived reference diagnosis. As such, the team evaluated the diagnosis of 240 patients, including 23 cases of invasive breast cancer, 73 ductal carcinoma in situ (DCIS), 72 cases with atypia (atypical hyperplasia), and 72 benign cases without atypia. "About 1.6 million breast biopsies are done every year in the U.S., yet in nearly half of the cases labeled atypia, our study indicates that there simply isn't 'concordance,' meaning there is not agreement with a standard reference diagnosis," explained Dr. Tosteson in a recent
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