Targeting Cellular Quality Control Mechanisms Increases Efficacy of Breast Cancer Chemotherapy Drug

Targeting Cellular Quality Control Mechanisms Increases Efficacy of Breast Cancer Chemotherapy Drug
Researchers from the University of Rochester Medical Center (URMC) in Rochester, NY recently released the results of a study that provides evidence of a treatment strategy that could increase the effectiveness of a chemotherapeutic agent’s ability to kill cancer cells. The study entitled, “Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics,” was published in the latest edition of Nature Communications. The study was conducted in the laboratory of Dr. Lynne E. Marquat, PhD, J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics, Director of the Center for RNA Biology,  Founder of the University of Rochester Graduate Women in Science Program, URMC.  For over 30 years, Dr. Marquat has conducted research into discovering new cellular pathways and clues to the molecular basis of human disease, with a recent focus on understanding t
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