Researchers are Predicting DCIS Recurrence Using Molecular Phenotyping

Researchers are Predicting DCIS Recurrence Using Molecular Phenotyping
Researchers have defined a molecular phenotyping method capable of predicting the chance of recurrence of both non-invasive and invasive breast cancer in patients diagnosed with ductal carcinoma in situ (DCIS). The researchers believe that molecular phenotyping, characterized by HER2 testing, could prevent overtreatment of DCIS patients. DCIS is the most common type of non-invasive breast cancer. While there are successful treatment options for DCIS patients, including breast-conserving surgery (BCS), mastectomy, and radiotherapy, DCIS patients typically exhibit a high rate of recurrence of both non-invasive and invasive breast cancer. As a result, women sometimes receive radical treatment methods to prevent recurrence, leaving a subset of patients at risk for overtreatment. Prior to this study, clinicians utilized estrogen receptor (ER) as a predictive marker for recurrence, which admittedly offered limited predictive power. HER2 is another predictive marker, however its prognostic significance remains controversial and therefore is not used by clinicians. The goal of this study was to analyze the ability of molecular phenotyping to accurately predict the chance of recurrence and, therefore, better dictate individualized treatment plans. A total of 314 patients were subdivided into four molecular phenotype groups based on their ER, HER2, and progesterone (PR) status: Luminal A (ER or PR+, HER2-), Luminal B (ER or PR+, HER2+), HER2 type (ER and PR -, HER2+), and triple negative (ER, PR, HER2 -). Overall, the molecular phenotype with the least rate of recurrence was Luminal A. In fact, Luminal A patients had only a 7.6% general recurrence rate after both 5 and 10 years and only 1.3% inva
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