Long-term Consumption of Soy Foods in Mice Reduces Recurrence of Breast Cancer

Long-term Consumption of Soy Foods in Mice Reduces Recurrence of Breast Cancer
Results from a recent study revealed that in animals, a long history of eating soy foods enhances the immune response against breast tumors, reducing cancer recurrence, contrasting with the notion that in women with breast cancer, eating soy foods or soy-based supplements can interfere with anti-estrogen treatment. The study, which may offer good news to women who regularly consume soy foods as part of their diet, was conducted at the Georgetown Lombardi Comprehensive Cancer Center and will be presented at the 2015 Annual Meeting of the American Association for Cancer Research (AACR), "I am concerned that some patients may start taking soy supplements when they shouldn't and that others will stop eating soy foods when they could really benefit from them," said the study's lead investigator, Leena Hilakivi-Clarke, PhD, professor of oncology at Georgetown Lombardi in a recent news release. Studies in mice that lack cytotoxic T cells, known to attack breast cancer, have shown that soy, precisely genistein (an isoflavone) can incite breast cancer cells to grow and interrupt anti-estrogen treatment, which led oncologists to advise their patients not to eat soy foods. Hilakivi-Clarke and Xiyuan Zhang, doctoral student and lead author of the current study, determined in previous research that mice that consumed genistein during their lifetimes responded better to anti-estrogen treatment when compared to control mice. These mice also had a reduced risk of cancer recurrence. Genistein, found in all soy-derived foods, have
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