Inflammation May Promote Breast Cancer Spread

Inflammation May Promote Breast Cancer Spread
Inflammation is a normal bodily process that helps ward off disease and protect against infections. Following an injury, inflammation can help the body to recover. But if inflammation is chronic and persistent, this could lead to cancer, including breast cancer. Researchers at Charles E. Schmidt College of Medicine at Florida Atlantic University published a new study that sheds light on this process. The article, “Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,” appeared in the Journal of Leukocyte Biology. The study focused on a biomarker of cancer known as“chitinase-3-like-1” or “CHI3L1.” Biomarkers refer to biological indicators that are different (such as increased) in a disease state compared to a non-diseased state. CHI3L1 is found in inflamed tissue, causing increased metastasis and faster cancer growth in that tissue. Metastasis refers to the growth of cancer at a new site in the body, distant from the original cancer site and is responsible for about 90 percent of all breast cancer deaths. “Important findings from our research show how pre-existing inflammation may be one of the factors that accelerates metastasis to the inflamed site,” remarked Vijaya L. Iragavarapu-Charyulu, Ph.D., the principal investigator of the study and associate professor of biomedical science in FAU’s Charles E. S
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