Breast Cancer Metastasis May Be Controlled by RNA Editing of Tumor-Promoting Gene

Breast Cancer Metastasis May Be Controlled by RNA Editing of Tumor-Promoting Gene
Wistar Institute researchers studying the genes and molecules involved in breast cancer progression have found that a gene previously thought to be present only in brain tissue promotes metastasis in vivo, and correlates with poor breast cancer survival. Importantly, researchers also found that an edited version of this gene suppresses breast cancer cell invasion and metastasis, highlighting the importance of RNA editing in this malignancy. The research paper, “The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis,” was published in Nature Communications. Cancer stage at diagnosis determines determinant not only the treatments given to patients but also their chances of survival. According to the National Cancer Institute, the five-year survival for localized female breast cancer, or stage 1, is 98.6 percent. However, when the cancer has metastasized, referred to either as regional or distant, five-year survival can be as low as 25.9 percent. To investigate the genes involved in metastatic events in breast cancer, researchers analysed The Cancer Genome Atlas (TCGA) breast cancer data and found 41 genes that were inversely correlated with cancer survival. The study mainly focused on the gene GABAA receptor alpha3 (Gabra3), a gene previously thought to be exclusive to adult brain tissues. The team found that this gene is highly expressed in breast cancer tissues, but not in healthy breast tissue. Furthermore, researchers showed that cells expressing Gabra3 had
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One comment

  1. Willie Carol Hildebrandt says:

    How long does the average patient take Xeloda?.I’m on 2000 mg am and 2000 mg pm 7 days on 7 days off et

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