Breast Cancer Patients May Benefit from Kataegis Multi-Mutation Phenomenon

Breast Cancer Patients May Benefit from Kataegis Multi-Mutation Phenomenon
Research on kataegis — clusters of mutations in some hotspots in a genome — is revealing that the phenomenon plays a positive role in breast cancer by rendering tumors less invasive and offering patients a better prognosis. Kataegis, the ancient Greek word for thunder, had been studied in breast cancer but researchers only recently determined if the thunderstorm of mutations are bad or good news. The study, Kataegis Expression Signature in Breast Cancer Is Associated with Late Onset, Better Prognosis, and Higher HER2 Levels, was published in the journal Cell Reports. In a press release, senior study author Kelly Frazer, a professor of pediatrics and director of the Institute for Genomic Medicine at University of California, San Diego School of Medicine and Moores Cancer Center, confirmed findings. "We don't know what causes kataegis, and before this study not much was known about its functional importance at the molecular or clinical level," Frazer said. "We've now found that kataegis is associated with a good prognosis for patients with breast cancer." Earlier studies showed that kataegis is present in about 55 percent of all breast cancers. Using available data from The Cancer Genome Atlas (TCGA), a National Institutes of Health's database with genetic profiles of more than 15,000 human tumors of various sorts, the research team identified 97 tumors with kataegi
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