Father’s Dietary Habits May Affect Daughter’s Breast Cancer Risk, Animal Study Suggests

Father’s Dietary Habits May Affect Daughter’s Breast Cancer Risk, Animal Study Suggests
A father's diet may influence his daughter's breast cancer risk, according to a new study in rats showing that the female offspring of male rats fed with high-fat diets before conception had a higher risk of developing breast cancer. The study, "Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets," was published in Breast Cancer Research. "Although in recent years, interest in the fathers' role in their offspring's health has grown, information concerning the influence of paternal factors on their daughters' breast cancer risk is very limited," study author Thomas Ong said in a press release. "In this study we have used a rat model to compare the impact of the consumption of high levels of animal or vegetable fat by fathers before conception on their daughters' risk of breast cancer." Investigators fed male rats either an animal (lard or pig fat) or vegetable (corn oil) high-fat diet — where 60 percent of the energy used by the animals was derived from fat — or a control diet, where only 16 percent of the energy came from fat. The rats then mated with females fed a standard laboratory diet. To understand how the father's diet influenced the risk of breast cancer in female offspring, the offspring were fed a standard laboratory diet and then induced with mammary tumors at 50 days of age. The researchers found that tumor cell death
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