Osteoporosis Treatment May Reduce Breast Cancer Recurrence and Metastasis, Study Finds

Osteoporosis Treatment May Reduce Breast Cancer Recurrence and Metastasis, Study Finds
Inhibition of the RANK pathway significantly reduces recurrence and metastasis in breast cancer mouse models, according to the results of a recent study published in Cancer Research. The study, "RANK signaling blockade reduces breast cancer recurrence by inducing tumor cell differentiation," shows that RANK inhibition reduces cancer stem cells (CSC) in invasive tumors, impairing the start of metastasis, and enhances sensitivity to chemotherapy. "Mortality in breast cancer is mainly due to survivor CSC after treatments, which are responsible for tumor recurrence and metastasis," Dr. Eva Gonzalez-Suarez, the study's lead author, said in a press release. "Previous studies of this and other research groups have shown that inhibition of RANK pathway may prevent breast cancer, but no one had proven the potential of RANK pathway inhibitors in the treatment of disease." In normal conditions, the RANK signaling pathway works to promote the development of the mammary gland in response to signals provided by sex hormones, such as progesterone. This usually happens in all women during their menstrual cycles and during pregnancy, but if the RANK signaling becomes disregulated, the mammary cells start reproducing rapidly when they are not supposed to, eventually leading to breast cancer. Expression of RANK in human cancers is linked with reduced overall survival, but the therapeutic potential of RANK inhibitors once tumors have devel
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