Dose-dense Chemotherapy Not Seen to Prevent Breast Cancer’s Return in At-risk Patients

Dose-dense Chemotherapy Not Seen to Prevent Breast Cancer’s Return in At-risk Patients
Tailored but heavy doses of chemotherapy given at shorter intervals do not seem to improve the chances of patients with early but high-risk breast cancer remaining cancer-free, compared to standard adjuvant chemotherapy, according to data from a recent clinical trial. Findings also showed that dense-dose chemotherapy appears to increase treatment-related side effects. The study, "Effect of Tailored Dose-Dense Chemotherapy vs Standard 3-Weekly Adjuvant Chemotherapy on Recurrence-Free Survival Among Women With High-Risk Early Breast Cancer," published in The JAMA Network, suggests that standard chemotherapy is a better overall treatment approach for these cancer patients. Most chemotherapy agents are dosed for each patient based on body surface area, but considerable differences are seen in how patients respond to both the therapy's effectiveness and its toxic effects. Patient-tailored and dose-dense treatments, which give the same total chemotherapy dose but over shorter periods, are being suggested as an alternative approach to improve the treatment's efficacy. Little is known about the approach's outcomes in breast cancer patients, leading researchers at the Karolinska Institutet and University Hospital, Stockholm, to conduct a randomized, open-label clinical trial (NCT00798070) in patients with early but high-risk breast cancer in Europe. The study assessed 2,017 women, randomly assigned to receive either tailored dose-dense chemotherapy (1,006 patients) or standard chemotherap
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  1. Jeanne Gari says:

    I had dose dense chemo in 2014 for stage 2 grade 3 tnbc and am left with constant pain neuralgia in my legs and feet. Debilitating. Also ended up with neutropenia and then again ended up with a blood transfusion. It was rough, but I’m still here.

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