Approved Therapy, Ibrance, Seen to Block Metastasis in Triple Negative Breast Cancer Study
Researchers may be one step closer to preventing triple-negative breast cancer, the most aggressive subtype of breast cancer, from spreading elsewhere in a person.
Ibrance (palbociclib), an FDA-approved drug for estrogen receptor-positive breast cancer, could also effectively block metastasis in triple-negative breast cancers, they report. The drug, however, did not affect growth in the original tumor.
The study, "CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1," was published in Nature Communications.
"Metastasis is a hallmark of cancer and a leading cause of cancer death," Zhenkun Lou, PhD, of Mayo Clinic, the study's senior author, said in a press release. "Despite great progress in cancer therapy, the prevention of cancer metastasis is still an unfulfilled challenge."
Lou and his team had a hint that inhibiting CDK4/6, which regulates a cancer metastasis protein, could influence the transition of immotile cancer cells into migratory cells — a process called epithelial-to-mesenchymal transition (EMT).
They focused particularly on triple-negative breast cancer cells because such cancers are known to grow the fastest and to be more metastatic than any other breast cancer subtype.
"Prior published data suggested that CDK 4/6 inhibitors were not effective in reducing the growth rates of estrogen receptor negative breast cancer," said Lou. "Our data confirmed that, while the rate of growth of triple-neg
So let’s get going on the HUMAN studies in Triple Negative!!!!! Hooray! A mouse survived!
Yeah… we hope so soon.
Please,rush this treatment and study, as my wife has TNBC,her sister died Oct. 2016 and her second sister died in May 2006. Her has had cancer for over 30 years.
I have recently had a lumpectomy for a stage 2 cat. 3 triple negative breast cancer. I had 25 rounds of radiation and now I just hope I am clear of cancer. Both parents had colon cancer and I am wondering if this is the same type of cancer they both had.Could Ibrance be taken by someone in my situation {clear at the moment} or does cancer have to be present.
I have triple neg breast cancer. I had a lumpectomy three weeks ago with clear lymph nodes. I am scheduled to start radiation in a week. Is this study warranted for me?