US Department of Defense Funds Phase 2 Trial of TapImmune Breast Cancer Vaccine

US Department of Defense Funds Phase 2 Trial of TapImmune Breast Cancer Vaccine
The U.S. Department of Defense (DoD) has awarded Mayo Clinic researchers $3.7 million to conduct a Phase 2 trial of TapImmune's HER2-targeted T-cell vaccine in women with the breast cancer known as ductal carcinoma in situ (DCIS). The 40 to 45 women who will be enrolled in the study, which is expected to begin this year, will receive the TPIV 110 vaccine six weeks before surgery to remove the tumor. "This is our second T-cell vaccine candidate to be tested in a DoD-funded Phase 2 study to the Mayo Clinic, and it marks our expansion into a second breast cancer indication," Dr. Glynn Wilson, chairman and CEO of TapImmune, said in a news release. "In addition to ongoing and planned Phase 2 studies of our lead TPIV 200 vaccine for treating triple-negative breast cancer, this new study of our HER2neu vaccine in DCIS has the potential to validate our novel approach to establishing lasting immunity against breast cancer and precancerous lesions." "Her2neu is overexpressed in about 30% of all breast cancer patients, amounting to approximately 220,00 patients per year," he added. "We look forward to the advancement of this fully funded study, as it further broadens our robust clinical pipeline, which also includes two additional Phase 2 trials for treating ovarian cancer." TapImmune's new T-cell vaccine targeting HER2 consists of five carefully selected HER2 antigens that do the best job of activating HER2-directed T-cells. The mix is expected to cover a significantly larger patient population than the HER2-targeted therapy Herceptin (trastuzumab). TPIV 110 is ex
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