30% of Aggressive Breast Cancer Patients Respond to Sacituzumab Govitecan, Trial Shows

30% of Aggressive Breast Cancer Patients Respond to Sacituzumab Govitecan, Trial Shows
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Thirty percent of patients with metastatic triple-negative breast cancer (TNBC) responded to the experimental therapy sacituzumab govitecan after failing to respond to other treatments, according to Phase 2 trial results.

Other measures of its effectiveness included the length of time patients responded to treatment, overall patient survival rate, and time to progression. The therapy was also well-tolerated, the team added.

The study, “Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer,” was published in the Journal of Clinical Oncology.

Sacituzumab govitecan is an antibody-drug conjugate composed of an anti-TROP-2 antibody linked to a toxic payload, SN-38.

TNBC patients, whose tumors lack estrogen and progesterone receptors and do not over-express HER2, lack targeted therapies. Chemotherapy is the current standard of care, but only 15 to 20 percent of patients with metastatic disease respond to it.

Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
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Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
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