Response to Neratinib and Xeloda Combo Seen in Breast Cancer Patients with Brain Metastasis

Response to Neratinib and Xeloda Combo Seen in Breast Cancer Patients with Brain Metastasis
Combining Puma Biotechnology’s candidate therapy PB272, also known as neratinib, with the chemotherapy drug Xeloda (capecitabine) appears to have therapeutic potential for patients with advanced HER2-positive breast cancer and brain metastasis, who were not previously treated with Tykerb (lapatinib), a clinical study reports. Results from the ongoing, multicenter Phase 2 trial (NCT01494662) found this combo therapy effectively shank metastatic brain tumors in nearly half of treated patients, and did so with tolerable toxicity. These positive results support further research into the use of neratinib to treat breast cancer patients with brain metastases. The findings were featured in an oral presentation, “TBCRC 022: Phase II trial of neratinib + capecitabine for patients (Pts) with human epidermal growth factor receptor 2 (HER2+) breast cancer brain metastases (BCBM),” given at the recent 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. The presentation is also available on Puma's website. “As a small molecule that can cross the blood brain barrier, neratinib potentially offers patients with HER2-positive metastatic breast cancer that has metastasized to the CNS a novel HER2 targeted treatment option,” Alan Auerbach, CEO and pr
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3 comments

  1. maureen martin says:

    am at a terrible cross roads…Since March 2016 major mets..first mets was in July 2013 breast met to lung…Faslodex for 1yr, Xeloda, combo, Ixempra, then Ibrance and Ibrance Faslodex…then in March 205,,mets to brain, rt eye, liver, al bones..cranium, ribs, spinal cord, etc., ,,then on Gemzar/Taxol from April 18th to Nov 5, 2016, Had Gamma Knife surgery for 4 lesions in brain also in April..then eye get better..no lesions…Oct 24…more brain lesion Drs. thought I had 6 when in for more Gamma Knife in late Oct ,7 hr. procedure 25 brain lesions….than in late Nov.. switched to Gemzar/Carboplatin….more liver increase switch in Jan to Halaven then approved for Opdivo in April…more liver smaller brain..took of Opdivo(as it takes 12 weeks to kick in…then on CMF…50% dosage chemo. NOW Brian has major swollen and bleeding not currently a candidate for whole brain…everyone is throwing in the towel??

    • SOG says:

      Hi , I am sorry about you having swollen and bleeding and not able to to WBRT, is this the only options given by doctor? I am having a difficult time deciding whether I should do WBTR or not for 20 lesions. I want try focal therapy first. I was initially scheduled for Gamma Knife for 4 lesions did a MRI right before that showed 20 lesions , so the Radiologist Onco told me I was not candidate to Gamma Knife any longer. Did I understand right that you had 7 hours procedure for 25 lesions? You did twice the SRST ? Can I ask where did you have done? I heard of others cases but could not convince my Radiologist. Hope you have got other treatment option. I can’t seem to get over the fear of whole brain radiation ..

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