Low Levels of Tumor Suppressor Protein May Predict Risk of Breast Cancer Recurrence, Study Says

Low Levels of Tumor Suppressor Protein May Predict Risk of Breast Cancer Recurrence, Study Says
Loss of a tumor suppressor protein called PTEN may predict the risk of breast cancer recurrence in patients who undergo radiotherapy, preclinical research shows. PTEN is a well-known tumor suppressor. It prevents uncontrolled cell growth, but because it is often mutated in human cancers, its deficiency contributes to the development of tumors. Low levels of the protein predisposes breast cells to defects that may promote the recurrence of cancer in response to radiotherapy. Screening the PTEN levels in breast cancer patients may help identify those who will benefit most from radiation therapy and those at risk of cancer recurrence due to the treatment.  At-risk women may benefit from combining radiation therapy with a specific type of inhibitor, the researchers found. The study, “Stromal PTEN determines mammary epithelial response to radiotherapy,” was published in the journal Nature Communications
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