Insight Into How Breast Cancers Evade Immune System Could Help in Developing Therapies, Study Says

Insight Into How Breast Cancers Evade Immune System Could Help in Developing Therapies, Study Says
Classifying breast cancers based on the mechanisms they use to avoid the immune system could be useful for designing effective immunotherapies for breast cancer patients, a study shows. The study, "Subgrouping breast cancer patients based on immune evasion mechanisms unravels a high involvement of transforming growth factor-beta and decoy receptor 3," was published in PLOS ONE. Although the body's immune system can recognize and kill tumors, cancers usually find a way to avoid being destroyed by immune cells. Immunotherapy works by activating the immune system against the tumor, and in some types of cancer, such as melanoma, there have been remarkable successes. However, immunotherapy hasn't been as effective in breast cancer patients. "We've been trying to understand why breast cancer patients do not respond well to the current immunotherapy and cannot benefit from this major breakthrough," Qing-Xiang "Amy" Sang, PhD, a professor of chemistry and biochemistry at Florida State University (FSU) and a co-author of the study, said in a press release. The goal of the study was to understand how different breast cancers try to avoid immune destruction. The researchers analyzed data from more than 1,000 breast cancer patients included in The Cancer Genome Atlas — a project aimed at cataloging genetic mutations responsible
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.