Changes in Gene Expression May Hint at Relapse Risk in ER-positive Patients on Hormone Therapy, Study Finds

Changes in Gene Expression May Hint at Relapse Risk in ER-positive Patients on Hormone Therapy, Study Finds
Specific changes in gene expression might help to predict the risk of relapse in estrogen receptor (ER)-positive breast cancer patients under hormone therapy, a study reports. The study, "Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumors," was published in Breast Cancer Research. Most ER-positive breast cancer patients are given hormone therapies that work to reduce tumor size and lessen their risk of dying from their cancer. However, a relapse risk remains constant in these patient for many years, even decades, probably because some tumor cells become resistant to the therapy and stay in the body as dormant tumors. The mechanisms that lead to acquired resistance and cause a dormant tumor to start growing again are unknown and difficult to examine. Researchers at the University of Edinburgh studied 62 breast cancer patients who did not undergo surgery – either because they declined or were unfit – and were treated with Femara (letrozole), a common hormone therapy, for at least four months and up to 45 months (almost four years). They took tumor samples before the women started therapy, and again within the first few weeks and then
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2 comments

  1. I HAD BREAST CANCER TWICE IN MY LIFE. I HAVE LOST MY BOTH BREASTS FOR CANCER. ONLY I HAD TREATMENTS. MY FIRST DIAGNOSED AT 2000 IN FEBRUARY BUT I HAD MASTECTOMY AT 7 MARCH 2000. I TOOK TAMOXIFEN TILL 2006 THEN CHANGED TO LETRAZOLE TILL 2009. MEAN TIME MY CANCER WAS RECURRENCED IN 2005 BUT MY SURGEON MEMBER DENIED TOLD NOTHING TO WORRY ABOUT. MY RECURRENCE SYMPTOMS ARE ORANGE PEEL, ITCHY, LARGER IN SIZE OF BREAST IN MY RIGHT BREAST WITH SHOOTING PAIN FROM BREAST TO UNDER ARMBIT. THEN 2017 I HAD MAMMOGRAM IT SHOW IN CIRCLE WHITE DOT. I HAD 2 BIOBSIES. I BELIEVED MY CANCER RECURRENCED IS INFLAMMATORY BREAST CANCER. AND I HAVE FAMILY CANCER HISTORY. MY MOM DIED BREAST CANCER. MY DAD AND YOUNGEST BROTHER DIED FROM CANCER AND MY YOUNGER BROTHER HAD THROAT CANCER. THIS JULY WILL BE 2 YEARS FOR MY DIAGNOSED AND I HAVE NEVER HAD ANY FOLLOW UP CHECK UP BY SURGEON OR ONCOLOGY BOTH LEFT ME BEHIND AND NO TREATMENTS AT ALL.

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