Cellular Barcoding Sheds Light on Spread, Drug Resistance of TNBC

Cellular Barcoding Sheds Light on Spread, Drug Resistance of TNBC
Very few cancer cells within a triple negative breast tumor (TNBC) are able to spread and grow in distant organs (metastasize), although most are able to shed from the original tumor and be resistant to therapy, a new technique called cellular barcoding has shown. Combining this advanced tool with animal models transplanted with patient-derived tumors, researchers at the Walter and Eliza Hall Institute of Medical Research in Australia have explored in detail the development of TNBC and its response to cisplatin chemotherapy. Although the results are preliminary and need to be confirmed in a real clinical setting, they may help to better understand how breast cancer evolves and refine treatment strategies. The study, “Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer,” was published in the journal Nature Communications.
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