Estrogen May Trigger Brain Metastasis in Triple-negative Breast Cancer, Study Shows

Estrogen May Trigger Brain Metastasis in Triple-negative Breast Cancer, Study Shows
Estradiol, a type of estrogen and the major female hormone, may drive the spread of cancer to the brain in women with triple-negative breast cancer (TNBC), a study in mice and human cells reports. Researchers identified a chain of molecular events triggered by estradiol that appears to be behind tumor cells' ability to form brain metastases. This process involves increased production of a brain-specific protein called BDNF and the activation of its receptor molecule, TrkB, in tumor cells. This discovery may have important therapeutic implications, since it provides a basis to use estradiol-depletion treatments or inhibitors that target this pathway to prevent or delay the spread of TNBC to the brain. The study, “Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote
Subscribe or to access all post and page content.

One comment

  1. І’m impressed, I have to admit. Seldom do I encounter a
    blog that’s both educative and engaging, and without
    a douƄt, you’ve hit the nail on the head. The issue
    is something that not enough folkѕ are speaking intelligently about.
    I’m very happy I came across this during my sеarch for sometһing regaгding thiѕ.

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.