Estrogen May Trigger Brain Metastasis in Triple-negative Breast Cancer, Study Shows

Estrogen May Trigger Brain Metastasis in Triple-negative Breast Cancer, Study Shows
Estradiol, a type of estrogen and the major female hormone, may drive the spread of cancer to the brain in women with triple-negative breast cancer (TNBC), a study in mice and human cells reports. Researchers identified a chain of molecular events triggered by estradiol that appears to be behind tumor cells' ability to form brain metastases. This process involves increased production of a brain-specific protein called BDNF and the activation of its receptor molecule, TrkB, in tumor cells. This discovery may have important therapeutic implications, since it provides a basis to use estradiol-depletion treatments or inhibitors that target this pathway to prevent or delay the spread of TNBC to the brain. The study, “Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote
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