Chemo Resistance in TNBC Due to Molecular Changes That May Be Treatable, Study Suggests

Chemo Resistance in TNBC Due to Molecular Changes That May Be Treatable, Study Suggests
Triple-negative breast cancer (TNBC) cells can become resistant to chemotherapy by temporarily turning on molecular pathways that protect the tumor, new research using mouse models and patient tumor samples uncovered. Since one of these pathways is a metabolic process possible to target, the study may offer new ways of treating resistant TNBC. The study, “Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state,” was published in the journal Science Translational Medicine. Current standard treatment for TNBC is frontline chemotherapy followed by surgery to remove the tumor, an approach that is highly effective in about half of all patients. “However, the remaining half of women will not fully respond to neoadjuvant [pre-surgery] chemot
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