Kisqali Prolongs Overall Survival in Advanced Breast Cancer Patients with Internal Organ Metastases

Kisqali Prolongs Overall Survival in Advanced Breast Cancer Patients with Internal Organ Metastases
Kisqali (ribociclib) combined with endocrine therapy prolongs the overall survival of women with HR-positive, HER2-negative, advanced or metastatic breast cancer with visceral metastases (in the soft internal organs), data from two Phase 3 clinical trials show. That finding was presented at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting, which took place May 29–31 in a virtual format. The presentation was titled “Overall survival (OS) in patients (pts) with advanced breast cancer (ABC) with visceral metastases (mets), including those with liver mets, treated with ribociclib (RIB) plus endocrine therapy (ET) in the MONALEESA (ML) -3 and -7 trials.”  Kisqali is a targeted therapy marketed by Novartis. It works by blocking the activity of cyclin-dependent kinases (CDKs), specifically CDK4 and CDK6, which are enzymes that regulate cell proliferation and growth, and often are overactive in breast cancer.  Kisqali in combination with the hormone therapy Faslodex (fulvestrant, marketed by AstraZeneca) as a first- or second-line therapy is being tested in the placebo-controlled MONALEESA-3 Phase 3 trial (NCT02422615). The trial enrolled 726 postmenopausal women with HR-positive, HER2-negative, advanced or metastatic breast cancer, Kisqali also is being tested in combination with other endocrine therapies — a non-steroidal aromatase inhibitor such as Femara (letrozole) or Arimidex (anastrozole) — or anti-estrogen therapy tamoxifen plus goserelin, in the placebo-controlled MONALEESA-7 Phase 3 trial (NCT02278120). The group that received tamoxifen plus goserelin was not included in the present analysis. The trial enrolled 672 pre/perimenopausal women with the same type of disease as those enrolled in MONALEESA-3. The pri
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