Tecentriq-Chemotherapy Combo Falls Short in TNBC Phase 3 IMpassion131 Trial

Tecentriq-Chemotherapy Combo Falls Short in TNBC Phase 3 IMpassion131 Trial
Tecentriq (atezolizumab) combined with chemotherapy failed to meet its primary endpoint of progression-free survival — the length of time during and after therapy in which the patient's disease does not get worse — for the initial (first-line) treatment of PD-L1-positive individuals with metastatic triple-negative breast cancer (TNBC). These are the findings of the multicenter Phase 3 IMpassion131 study (NCT03125902), which compared Tecentriq plus the chemotherapy paclitaxel to paclitaxel alone in 651 people with previously untreated, inoperable, locally advanced or metastatic TNBC. The study was sponsored by Genetech, a Roche subsidiary, which is developing the cancer immunotherapy
Subscribe or to access all post and page content.