Study Questions Benefit of Endocrine Therapy in Elderly Women with Low Risk Hormone Receptor Positive Breast Cancer

Study Questions Benefit of Endocrine Therapy in Elderly Women with Low Risk Hormone Receptor Positive Breast Cancer
shutterstock_149060039Researchers at Fox Chase Cancer Center have showed that combining endocrine therapy and radiation therapy for breast conservation of women with hormone-receptor positive (HR+) invasive breast cancer may not be necessary for all patients affected by the disease. The results, presented at the American Society for Radiation Oncology’s 56th Annual Meeting, showed that low-risk patients over 65 years old with small tumors could achieve the same survival rates after treatment with adjuvant radiation therapy without endocrine therapy. “When they’re treated with adjuvant radiation therapy alone, elderly women with small, low risk tumors may have acceptable results. Once their tumors start to get bigger, however, we identified an increasing risk for metastasis, and those people likely need to be on endocrine therapy”, Colin T. Murphy, MD, Radiation Oncologist at Fox Chase and lead author on the study said in a Fox Chase Cancer Center press release. Even though recent clinical trial results had demonstrated that endocrine therapy alone could accomplish positive outcomes in elderly women with low risk, early stage HR+ breast cancer, the effects of radiation therapy alone had not been tested yet in this
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