FDA Approves Phesgo as Injection Treatment for HER2-positive Breast Cancers

FDA Approves Phesgo as Injection Treatment for HER2-positive Breast Cancers
The U.S. Food and Drug Administration (FDA) has approved Phesgo, an under-the-skin injection of Perjeta (pertuzumab) and Herceptin (trastuzumab) with hyaluronidase, as a faster and more convenient alternative to treat people with HER2-positive breast cancer. The approval of this fixed-dose combination is for use with chemotherapy in early and metastatic breast cancers, the same indications for which the combination of intravenous (into-the-vein) Herceptin and Perjeta is approved. The original formulations required intravenous infusions given over 2.5 hours. Phesgo was developed by Genentech as an equally effective and safe option, given to patients by a healthcare provider as an injection into the thigh that takes less than 10 minutes. This subcutaneous injection can be administered at a treatment center or a patient's home. “Currently, most patients with HER2-positive breast cancer receive trastuzumab and pertuzumab at infusion centers. With a new administration route, Phesgo offers an out-patient option for patients to receive trastuzumab and pertuzumab,” Richard Pazdur, MD, director of the
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