Breast Cancer Vaccine Shows Promising Results According to Study

Breast Cancer Vaccine Shows Promising Results According to Study
shutterstock_38872966In a recent study titled “Safety and preliminary evidence of biological efficacy of a mammaglobin-A DNA vaccine in patients with stable metastatic breast cancer”, and published in the Clinical Cancer Research journal, a team of researchers from Washington University School of Medicine, St. Louis, evaluated the safety and biological efficacy of a breast cancer vaccine in patients suffering with the metastatic form of the disease. The results indicated this vaccine was able to activate the patient’s immune system, allowing it to attack cancer cells and therefore slower tumor progression. Researchers found that a protein called Mammaglobin-A (MAM-A) is expressed at high levels in 40% to 80% of primary breast cancers. As such, the new vaccine (MAM-A DNA) directs the patient’s immune system to target this protein, which is almost exclusive to breast cancer cells. "Being able to target mammaglobin is exciting because it is expressed broadly in up to 80 percent of breast cancers, but not at meaningful levels in other tissues," senior author William E. Gillanders, MD, professor of surgery said in a
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