Breast Cancer Cell Proliferation Inhibited by Targeting miR569

Breast Cancer Cell Proliferation Inhibited by Targeting miR569
shutterstock_189635594Gordon Mills, MD, PhD, a professor at The University of Texas MD Anderson Cancer Center, is finding ways to control the growth of breast and ovarian cancer tumors. His team recently published an investigation on a molecule-based approach that inhibits the destructive behavior of the genetic alteration known as the 3q26.2 amplicon using the non-coding microRNA miR569. "Small non-coding miRNAs represent underexplored targets of genetic aberrations and emerging therapeutic targets," Dr. Mills said in an MD Anderson news release. "We demonstrated that miR569, which is overexpressed in a subset of ovarian and breast cancers due in part to the 3q26.2 amplicon, can impact cell survival and proliferation." The research behind this finding was published in Cancer Cell, under the title "Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers." During the study, the researchers, including lead study author Pradeep Chaluvally-Raghavan, PhD, identified a mechanism of cancer cell proliferation that involved miR569 and tumor protein TP53INP1. "The study results clearly show that TP53INP1 is a key target of miR569 both in vitro and in vivo," Dr. Mills
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