MIT Researchers Identify New Family Of Proteins Involved In Breast Cancer Progression

MIT Researchers Identify New Family Of Proteins Involved In Breast Cancer Progression
shutterstock_170342009A recent study from MIT researchers published in eLife journal showed that a type of RNA-binding protein known as Musashi proteins, are involved in breast cancer regulation by increasing the proliferation rate of cancer cells. Previous studies had already demonstrated that this type of transformation was tightly regulated by transcription factors. However, this new study demonstrates that RNA-binding proteins, which can impact gene expression through messenger RNA regulation, also play a key role in this process. “Recent discoveries show that there’s a lot of RNA-processing that happens in human cells and mammalian cells in general,” lead author Yarden Katz, PhD, said in an MIT news release. “RNA is processed at several points within the cell, and this gives opportunities for RNA-binding proteins to regulate RNA at each point. We’re very interested in trying to understand this unexplored class of RNA-binding proteins and how they regulate cell-state transitions.” Not much was known regarding the biological functions of Musashi proteins, which until this study, had been used to identify neural ste
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