Researchers Discover Key Gene Involved In Breast Cancer Progression

Researchers Discover Key Gene Involved In Breast Cancer Progression
shutterstock_126772121A recent study published in Science Signaling has revealed a crucial gene that can partially explain how the TGF-beta protein can simultaneously stop cancer progression and encourage its growth. Usually, TGF-beta works as a tumor suppressor, providing cells the necessary signals to grow in a controlled manner. However, sometimes this protein can completely change its function, transforming itself into a tumor promoter, pushing tumor growth and malignancy. In their study, researchers from the University of Michigan Comprehensive Cancer Center have found Bub1 as one of the main genes involved in TGF-beta receptor regulation. “Our data that Bub1 is involved at the receptor level is completely unexpected,” study author Alnawaz Rehemtulla, Ph.D., Ruth Tuttle Freeman Research Professor of radiation oncology and radiology and co-director of the Center for Molecular Imaging at the University of Michigan Medical School, said in a news release. “Bub1 is well-known for its role in cell division. But this is the first study that links it to TGF-beta. We think this may explain the paradox of TGF-beta as a tumor promoter and a tumor suppressor,” he
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