Antiestrogen Therapy Resistance Mechanism Identified

Antiestrogen Therapy Resistance Mechanism Identified
apoptosisBreast cancer is a problem best solved by a multidisciplinary team. As such, a collaboration between biologists, physicists, and engineers at Georgetown Lombardi Comprehensive Cancer Center and Virginia Tech have embraced this fact to discover a new way to predict the outcome of antiestrogen therapy. The team, led by Robert Clarke, PhD, DSc, of Georgetown, and William T. Baumann, PhD, of Virginia Tech, found a relationship between interferon regulatory factor-1 (IRF1) and autophagy regulator ATG7 that has implications in human breast cancer cell fate. "We needed an engineering approach to a biological problem--no one had built a model like this before," said Dr. Clarke in a news release from Georgetown. The group described a study designed to look at living cells from the perspective of an information processing system in their article, "Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophage and Apoptosis to Determine Breast Cancer Cell Fate," published in
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