Minimally Invasive Breast Cancer Cryotherapy Largely Ignored in U.S., Says Advocate and 13-Year Survivor

Minimally Invasive Breast Cancer Cryotherapy Largely Ignored in U.S., Says Advocate and 13-Year Survivor

PaulLauraLaura Ross-Paul of Portland, Oregon, calls herself a “patient pioneer,” as one of the first women in the world to receive cryoablation as the primary treatment for her multi-focused breast cancer 13 years ago.

Cryotherapy, also called cryosurgery, cryoablation or targeted cryoablation therapy, is a minimally invasive procedure that uses the application of extremely cold temperatures (cryo) to destroy diseased tissue (ablation), including cancer cells.

For internal tumors, cryotherapy is carried out by using a cryoprobe — a thin hollow wand-like device with a handle or trigger or a series of small needles, attached via tubing to a source of nitrogen or argon, which super-cools the probe tip through which cooled, thermally conductive fluids are circulated. Cryoprobes are inserted into or placed adjacent to diseased tissue in a way that ablation will provide correction, yielding benefit to the patient.

The cryoprobe is placed in the proper position using imaging guidance, and as internal tissue is being frozen, the physician avoids damaging healthy tissue by viewing movement of the probe on ultrasound, computed tomography (CT) or magnetic resonance (MRI) images transmitted to a video monitor. With the probes in place, the cryogenic freezing unit removes heat from the tip of the probe and by extension from surrounding tissues.

Ablation occurs in tissue that has been frozen by at least three mechanisms:
• Formation of ice crystals within cells, thereby disrupting membranes and interrupting cellular metabolism among other processes;
• Coagulation of blood thereby, interrupting blood flow to the tissue, in turn causing ischemia and cell death;
• Induction of the so-called programmed cell death cascade.

KarmanoslogoRoss-Paul received her cryotherapy treatment in 2003 at the Karmanos Cancer Center in midtown Detroit, Michigan, NCIlogoone of 41 National Cancer Institute-designated Comprehensive Cancer Centers in the U.S. and the only hospital in Michigan dedicated exclusively to fighting cancer.

With continuing improvement of imaging techniques and development of devices that can more precisely control the topical application of extreme temperatures to better control extreme temperatures, Karmanos Cancer Center physicians use cryotherapy as a treatment for patients with skin tumors, precancerous skin moles, nodules, skin tags, or unsightly freckles. They can also use cryotherapy to treat patients with benign and malignant breast tumors, although cryotherapy to treat malignant breast tumors is still considered experimental, and certain other cancers, including cancers of the prostate, liver (usually metastasized from other organs), cervix, and fibroadenoma.

Cryotherapy Benefits

Compared with other techniques, one of the benefits of cryotherapy includes minimal pain, minimal scarring, lower cost, and faster recovery times. The Karmanos Cancer Center, which is affiliated with Wayne State University’s School of Medicine, explains that once diseased cells are destroyed, components of the immune system clear out the dead tissue, and that patients undergoing cryosurgery usually experience minor to moderate localized pain and redness, which can be alleviated by over the counter painkillers such as aspirin or ibuprofen, and application of topical steroid creams.

Blisters may form, but they usually scab over and peel away. As with any medical treatment, there are risks involved, primarily damage to nearby healthy tissue and the potential for not thoroughly freezing the entire tumor during treatment. Damage to nerve tissue is also of particular concern.

Now a cryotherapy activist and advocate, Ross-Paul says that while to date there have been several dozen patients treated by cryoablation for breast tumors by Dr. Peter Littrup, a pioneer in the cryotherapy field, the Chinese, who began using cryoablation to treat breast cancer about the same time as Littrup, have treated more than 3,800 women using the method.


“The fact that these tremendous advances in China have not been duplicated in the U.S. is disturbing,” Ross-Paul said. “As activists promoting cryoablation in America, I and my husband have tried to identify why the progress in America is so slow, and then conceive of a solution to this problem. We believe we have the answer.”

Ross-Paul contends that “in America, cryoablation is seen as a treatment that needs to be proven effective before it is considered a safe alternative to the mastectomy and lumpectomy. FDA trials have been undertaken in the last 13 years, but the size of the trials have been limited due to financial constraints. As a result, when a doctor advises their patient who has breast cancer, cryoablation is considered as an unproven, experimental alternative to the much safer and statistically proven surgery.”

“Without statistical proof through trials,” she said, “cryoablation wont be used. But if cryoablation isn’t used, there will be no statistics. This has doomed cryoablation in the U.S. to forever be an experimental treatment. To get around this dilemma, we believe that prevention is the key. Through early detection, women are finding something suspicious in a mammogram. Since it is not yet identified as cancer, they are told to wait and see if it develops. If it doesn’t, after a long time of fearful waiting, there is a joyful sigh of relief. If it is cancer, however, at that point, cryoablation is not considered and only surgery is advised.”

What Women Want

But “women don’t want to just wait and do nothing,” Ross-Paul said. “In this six month wait-and-see period they are ready for action. The solution is to develop a new protocol that accompanies early detection, and that would be to use cryoablation to freeze anything suspicious. Why wait for something to manifest as a tumor? Why not keep the patients’ safety uppermost in mind and ablate the unusual tissue, and then follow up with more imaging? Cryoablation can’t hurt the breast, it is almost painless and very inexpensive. And if something suspicious returns, use cryoablation again until the condition either goes away, or becomes an obvious tumor which can then be treated by cryoablation, or by surgery.”

Ross-Paul maintains that if this new protocol is used in enough patients, the power of the naturally occurring immune effect will start to show itself, noting that “each time something suspicious is frozen and it was actually breast cancer, then about half those cases will be put into remission. Over time, a statistical base will demonstrate that women treated through early, preventative cryoablation develop far less breast cancer than those who simply wait, if they continue to engage in early detection combined with cryoablation.”

“There is no need to prove that cryoablation is superior to or as effective as surgery,” Ross-Paul said, “although efforts to do so can and should continue on a separate track. It can prove itself through this new protocol by eventually reducing the incidence of breast cancer almost entirely. This is what women need. This is what women want.”

PaulalexanderRoss-Paul has co-written a book with her husband, Alex Paul, and her cancer physician, Dr. Peter Littrup, titled “They’re Mine and I’m Keeping Them,” which documents the story of how she and her husband bucked the system and found Littrup, whose Littruppeteradvanced skill in the field of cryo-ablation ultimately saved her breast. The co-authors also relate the success at Fuda Hospital in Guangzhou, China in treating a variety of Stage 4 cancers by combining cryoablation and advanced immune system therapies, which increase the frequency of the occurrence of the natural immune effect to approximately 80 percent or higher of the cases.

“They’re Mine and I’m Keeping Them” is available from in both hard copy and ebook (Kindle) versions. Ross-Paul also maintains a Web page: and a Facebook site:

Through her several avenues of outreach, Ross-Paul says she has helped a handful of women receive cryoablation treatment by Littrup, and “has learned that women need a cure for cancer, and they want that cure to not involve losing their breast through a mastectomy or disfiguring it with a lumpectomy.”

She said that “while a cure for breast cancer might someday achieve these goals through the simple action of taking a pill, that day has not yet come,” and that “in the meantime, cryoablation can put breast cancer in remission, giving women what they need, and not disfigur[ing] a woman’s breast, thus giving women what they want.”

“The beauty of cryoablation,” Ross-Paul said, “is that it is breast conserving — I was able to avoid a mastectomy,” its low morbidity — “I never needed more than a Tylenol,” and its inexpensive cost compared to surgery. Ross-Paul says another major benefit of cryoablation is that in about half of all cases, “cryoablation naturally stimulates the body’s immune system to develop an immunity to the cancer as it eats up the now-dead tumors.”

Ross-Paul has recently been asked to speak at the 5th International Forum on Cancer Treatment to be held July 1-3 in Guangzhou, China, which will be her second speaking engagement at this forum. The focus of the 2016 forum will be on treatment of cancer by cryosurgery, irreversible electroporation (IRE), immunotherapy, and stem cell treatment for cancer.

The forum is organized by the International Society of Cryosurgery and Asian Society of Cryosurgery, Fuda Cancer Hospital, Jinan University School of Medicine, and the First Affiliated Hospital of Shenzhen University. The organizers have invited experts and peers from around the world, including America, the U.K., Japan, Australia, and other authorities.

“I appreciate the forum organizing committee’s inclusion of a patient pioneer to speak alongside the doctors and researchers,” Ross-Paul said.


  1. What pisses me off about this excuse for not using cryoablation (to wait and see) is that’s it’s complete nonsense. Why do doctors perform colonoscopies starting at age 50? They go in and anything that looks suspicious, such as colon polyps, are removed as a preventative measure. Why is there any difference when it comes to breast cancer and preventive care? Someone needs to answer this question.

  2. Nedra Kissling says:

    Are there any doctors in Arizona that will perform the procedure? Or any other state? I have a 3+cm breast tumor and have been treating it holistically myself since February 2, 2016. I would like to get the cryoablation procedure done on this tumor. Thank you for your help.

    • Lori says:

      There is a doctor in San Diego named Dr Stryker who is one of the best doctors out there performing this procedure.

    • Angellee Darger says:

      Yes. Dr. Stryker in San Diego, California does this and she is very good. Look her up on the internet. I’ve heard great things about her and her patients.

    • Elim says:

      My mom is getting this procedure today in Atlanta. I’m very excited. She’s been strong, but had more than a few problems during this whole procedure.

    • Todd Goodwin says:

      I am the Georgia distributor for Sanarus Technologies, a company that specializes in the cryoablation of breast cancer. Our system is FDA approved and backed by a 5 year NCIS study which showed superior results compared to excision. The website is . There is a toll free number under the “contact us” heading.

    • Lori says:

      There is a doctor in San Diego named Dr Stryker who is one of the best doctors out there performing this procedure.

      • Amy says:

        Hi Lori,

        I checked out Dr. Stryker’s website but don’t see her name mentioned anywhere else. How do you know she’s one of the best doing cryoablation?


    • Janice says:

      I had it done by Dr. Littrup in Rochester Hills, Michigan at Crittenton Hospital. He is no longer at Karmanos, as stated in the article. The surgery was done a year ago on a breast cancer reoccurrence, and so far, it has been completely successful.

  3. Elim says:

    I can’t edit my comment, I meant to say my mom is getting this procedure done today in Atlanta. I’m very excited. She’s been strong, but has had more than a few problems during her whole breast cancer TREATMENT (prior to the procedure). I will try to remember to post how it goes.

  4. Izzy says:

    Doctors in America use wrong kind of gas, I had it done in Austria and was told that the temperature has to be -180 celsius where in the UŠ they only mannage to bring IT to -60. It is not in the interest of medical care to Save us but to make money. I was treated at Cedars in LA and after 6 surgeries, chemos, radiation etc came to look for Solutions in EUROPE. Austria and Germany are saving many lifes not killing people with drugs like back Home. If you can afford it don’t wait.

    • Kelly says:

      Izzy, Where in Austria did you go? I am newly diagnosed and trying to find resources for cryoablation. I know that Fuda hospital in Guangzhou does it, so I’m considering that option.

      • izabela says:

        The treatment in Austria is done by Professor Nikolai Korpan in Vienna, he treats 95% of cancer patients (not only breast) with cryosurgery. You can tell him that Izabela gave contact so it will be cheaper. The hotel nearby is Kaiser Franz Joseph, if you book directly with hotel it’s cheaper then on internet.
        Here is the address
        40 Google reviews
        Private hospital in Vienna, Austria
        Address: Billrothstraße 78, 1190 Wien
        Hours: Open today · Open 24 hours
        Phone: 01 360360

        • Gandhi says:

          Hello Izabella,

          Please let me know the approximate range of the costs for cryoablation/cryosurgery. Thanks a lot. Kindly reply ASAP. Thanks again

        • Abelha says:

          Hi Izabela, I have an triple negative large invasive ductal carcinoma and I’m interested in in Cryo. I’m in the UK, so Austria would be closer for me. Could you tell me the name of the hospital there?

      • Cindy says:


        I was on this site after researching cryoablation a bit more for a friend who has BC. My 17 yr old son had testicular cancer last year and after surgery and chemo, has a residual teratoma tumor that requires a horrific surgery. Through a friend who is a nurse, we found a fantastic interventional radiologist in Jacksonville who did a cryo procedure on his tumor. He could only get half of it due to the location near the aorta, but we just had a scan and are hoping it shrunk enough that he can get the remaining half. We’ll do anything to avoid cutting him from chest to pelvis with 6 days in the hospital and 6 weeks of recovery. It has shrunk some, we can tell looking at the scan ourselves. We are in Jacksonville and seeing Dr. Jamie Edwards at Saint Vincents Hospital in the Interventional Radiology dept.

        I’ll email you my contact info.


  5. Carolyn says:

    Hi Izmir, I am also interested and want to find out if I am a candidate for this. I have triple negative breast cancer that has shrunk significantly with chemo. What are the hospitals that perform this procedure according to the correct temperatures? Interested in either Germany or Austria, or anywhere in Europe. Please hurry my dr. Want some to do surgery soon.

  6. Jerry Czarnecki says:

    Whatever you do, be aware that biopsies {both incisional and needle-type) often seed (disseminate) cancers and make cancers more aggressive. This has been documented in the medical literature for three decades: “Biopsies increase the virulence of existing cancers”, ” .””As much as 20% of metastases could occur because of an incisional biopsy and would not have occurred if the tumor were not violated before its excision”. “Numerous case reports of malignant seeding resulting from needle biopsies have been reported for different tumors.” „When probing for breast cancer, tumor cells in the blood droplets were present in 74% cases in blood passing the skin orifice, with the potential of seeding cancer.“ With other cancers, like liver cancer or skin melanoma, the deadly effect of biopsies is even much higher: up to 44%. This seems to be an un-mentionable taboo in the medical community.
    Biopsies are not only harmful, they are also outdated, and their sampling is unreliable. There is about a dozen of new instrumental methods: MRI, Contrast Ultrasound, RT-PCR, CT-scan, “Liquid Biopsy” (“Circulating Tumor Cells” method, nothing to do with needle biopsies) provide vastly richer information, without causing the cancers to proliferate. Company Cynvenio (Westlake Village, California) is offering now breast-cancer test based on analysis of blood samples “which dentifies circulating tumor cell and detects emergent genetic alterations associated with resistance to therapy, and has been optimized to monitor patients with advanced breast cancer during initiation of therapy and at regular intervals following treatment.” “Cynvenio’s liquid biopsy blood tests accurately target known DNA & RNA mutations in cancer-related genes to revolutionize personalized treatment decision making and clinical trial selection”
    That was about diagnosis. The traditional treatment of breast cancer pales by comparison with cryo-ablation: “Almost half women with early stage, invasive breast cancer report severe or very severe side effects from their treatment.” “”As an oncologist, I knew from my clinical practice that more women were suffering than is generally reported in clinical trials,”” said Allison Kurian, MD, MSc, an associate professor of medicine and health research and policy at Stanford University.”

  7. Eva Aldrich says:

    I am in Kentucky and am looking for a physician to treat my breast cancer with cryoablation. Please email me and let me know how I can contact Dr. Littrup or another doctor who might be willing to treat me.

    • Janice says:

      Eva, Dr Littrup is at Crittendon Hospital in Rochester Hills, MI. He is one of the best in the world. He just performed cryoablation on me last week.

  8. Jennifer says:

    Hello, thank you for this informative article. I was just diagnosed with 8mm invasive carcinoma. I am close to Los Angeles. Do you know of a doctor in the area with expertise in this procedure.

    And do you know names of doctors in Europe? I just moved back to the States from Europe two months ago and I would be happy to go back for treatment.

  9. Lisa says:

    I can personally recommend Dr. Jason Williams who performs cryoablation and researches immunotherapies, of Williams Cancer Institute.

    I recently met a lung cancer patient of Dr. Williams, who was told by Cancer Center of America they were not a cryoablation candidate, since it was not accessible.

    May we join together to speak up about the corruption within the USA medical system.

    May we only choose to support the pay checks of medical professionals, or any person, who will do the right things for human kind.

    • izabela says:

      Hi Lisa,
      I was told that they don’t do it right in the US, the temperature is nt cold enough, it has to be minus 180 celsius. Look up in comments I left the name and info of the best doctor in the field. Was treated at Cedars Sinai in LA

      • Diana Tucker says:

        There is a new company in San Diego that can get down to below 180. They have been talking to Dr Susan Love who advocates this idea if freezing BEFORE it becomes cancer but they need investors to bring it to market. Also, a group question: if insurance won’t cover it, would u pay cash out of pocket?

  10. Nancy says:

    Hello does anyone know if conventional adjuvant treatment (like radiation/medication) is needed after cryoablation?

  11. lee grobbelaar says:

    Hi, I am hoping this will be an answer for a pleomorphic liposarcoma of the arm, it is also visible under my skin. Currently have very aggressive and ugly proposed surgery would like to explore this as a possibility I am in South Africa. Germany would probably be the best place for me to go?
    Can anyone advise on this

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