Exemestane and Everolimus: Hormone and Biological Therapy Treatment Combination

Exemestane and Everolimus: Hormone and Biological Therapy Treatment Combination

Exemestane

Exemestane, also known as Aromasin,  is a type of oral, targeted cancer therapy called an aromatase inhibitor and works by a mechanism that stops the production of estrogen in postmenopausal women by blocking an enzyme called aromatase., which is important in the production of estrogen. Inhibiting the actions of aromatase means less estrogen is available to stimulate the growth of hormone-receptor positive breast cancer cells. Exemestane dissolves in the digestive system and is absorbed into the blood stream, where it blocks the production of estrogen from fat tissue.

Everolimus

Everolimus, also known as Afinitor, is a biologic immunosuppressant therapy that was first used to prevent the body from rejecting organ transplants. It has been repurposed as an oncology therapy that helps estrogen-blocking cancer drugs, such as exemestane, to sustain their estrogen-blocking mechanism for longer periods of time.

Benefits in Combining Exemestane and Everolimus

The combination of exemestane and everolimus has shown to be significantly more effective in the increase of progressive-free survival of patients than with the hormonal therapy alone. The two drugs work together to stop the growth of cancer cells, and this significant treatment response only works when the drugs are used in combination. In the clin
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