Blocking Breast Cancer Cell Energy Pathways Could Help Fight Disease, Study Finds

Blocking Breast Cancer Cell Energy Pathways Could Help Fight Disease, Study Finds
A collaborative research study led by researchers at Thomas Jefferson University revealed that energy processes used by breast cancer cells could differ from those of healthy cells, possibly leading to the development of new ways to manage breast cancer tumors. The study, "TIGAR Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer," were published in The Journal of Biological Chemistry. According to estimates from the National Cancer Institute, breast cancer, which affects around 12.4 percent of women worldwide, is caused by an abnormal growth of breast cells. Although major advances have already been made in understanding breast cancer and developing several therapeutic approaches for the disease, there is still much that researchers don't understand about the detailed mechanisms involved in its development. In this study, researchers investigated the energy mechanisms used by breast cancer cells in transforming calories into energy. They focused on a particular protein, called TIGA, which is known for its involvement in breast cancer cells' reduced ability to transform sugar into energy. They examined how TIGAR levels influenced breast cancer cells and the surrounding fibroblasts (breast connective tissue cells), as well as the tumor growth. The researchers found that breast cancer cells producing high levels of the TIGAR protein depended more on mitochondrial energy production pathways. Interestingly, w
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