New Guidelines for Advanced Breast Cancer Treatment Discussed at ABC 4 Conference

New Guidelines for Advanced Breast Cancer Treatment Discussed at ABC 4 Conference
Clinical trials for hormone-dependent advanced breast cancer should be less restrictive in the criteria used to determine who can participate, and they should allow pre-menopausal women — who account for a third of these cancer cases — to participate, clinical experts state. An expert panel recently convened during the Advanced Breast Cancer Fourth International Consensus Conference (ABC 4) to define new guidelines for treating advanced breast cancer. The panel, composed of 1,300 experts and patients from 88 countries, called for future trials designed to enable both pre- and post-menopausal women to take part, helping doctors identify new treatments for a patient population with limited treatment options. “At present, not only are younger women denied the opportunity to take part in clinical trials, but also clinicians lack the evidence on how best to treat these patients who have advanced breast cancer with limited therapies available,” professor Fatima Cardoso, director of the Breast Unit at the Champalimaud Cancer Centre in Lisbon, Portugal, and chair of the ABC 4 conference, said in a press release. Many women have estrogen receptor (ER)-positive breast cancer, which involves tumors that are "fed" by the female hormone estrogen. In pre-menopausal women, estrogen is produced by the ovaries, and women are treated by either permanently removing the ovaries or with drugs that temporarily halt estrogen production. Such methods cause women to enter menopause. “This ‘induced menopause’ means that including these younger women in trials alongside older women is unlikely to hamper the research. On the contrary, it migh
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One comment

  1. john stewart says:

    Although mostly found in women, men can get breast cancer too. There are a number of symptoms associated with breast cancer, but the first noticeable symptom is often a lump or area of thickened breast tissue. A lump in the breast does not necessarily mean you have cancer – most breast lumps are not cancerous. However, it is always best to have them checked by your doctor. Treatment for breast cancer may include surgery, radiation, chemotherapy, hormone therapy, targeted therapy or bone-directed therapy.
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