Patient Dosing Begins in Phase 2 Trial of MCLA-128 in Metastatic Breast Cancer

Patient Dosing Begins in Phase 2 Trial of MCLA-128 in Metastatic Breast Cancer
The first patient in the Phase 2 clinical study of MCLA-128 in metastatic breast cancer patients has been dosed, The Netherlands-based immuno-oncology company Merus recently announced. The international study (NCT03321981) is assessing MCLA-128 in two types of metastatic breast cancer patients, including HER2-positive and hormone receptor positive/HER2-low patients. MCLA-128 is a full-length bispecific antibody that targets HER2 and HER3 receptors. The antibody is the most-advanced of its kind, referred to as Biclonics. MCLA-128 was engineered to overcome the resistance of cancer cells to HER2-targeted therapies by (1) blocking cellular growth and survival while simultaneously preventing tumor cells from escaping the therapy through activation of the HER3 molecular pathway, and (2) recruiting immune cells to kill the tumor. MCLA-128 was modified to enhance the immune cells’ ability to target the tumor. Merus anticipates enrolling 120 patients in locations across Europe and the U.S. The first group will be composed of HER2-positive patients progressing on anti-HER2 therapies. Patients will receive MCLA-128 in combination with Herceptin (trastuzumab, by Genentech) and chemotherapy. In preclinical tests, MCLA-128 and Herceptin inhibited tumor cell growth regulated by HER3. The second group will be comprised of metastatic breast cancer patients with hormone receptor positive status and HER2-low who are receiving hormone therapies and CDK4/6 inhibitors. Participants will receive MCLA-128 in combinati
Subscribe or to access all post and page content.

One comment

  1. Lynn Brettle says:

    Such exciting progress. Please keep me updated as although I’m NED at present I’m in the high chance of recurrence due to it being locally advanced HER 2 positive. Also oestrogen positive.
    Thank you .

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.