Adding Ibrance to Hormone Therapy Fails to Prolong Time Before Cancer Recurs, Trial Shows

Adding Ibrance to Hormone Therapy Fails to Prolong Time Before Cancer Recurs, Trial Shows
Adding Ibrance (palbociclib) to standard endocrine therapy failed to prolong the time women with early hormone receptor (HR)-positive, human epidermal growth factor (HER2)-negative breast cancer lived without having their disease return or spread, according to data from a Phase 3 trial. The study, called PENELOPE-B (NCT01864746), was designed to assess if the addition of Ibrance with five years of standard adjuvant endocrine therapy would be superior to a placebo plus standard hormone therapy at prolonging the time women lived without having their cancer spread or return — a parameter known as invasive disease-free survival (iDFS). Adjuvant therapy is a treatment normally given after surgery to prevent cancer from returning. Sponsored by The German Breast Group (GBG) as part of a clinical research collaboration with Pfizer and other study groups, PENELOPE-B enrolled a total of 1,250 pre- and post-menopausal women from more than 190 clinical
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