Strict Diet Starves Breast Cancer Cells and Boosts Chemotherapy’s Effects in Animal Study

Strict Diet Starves Breast Cancer Cells and Boosts Chemotherapy’s Effects in Animal Study
A very low-calorie, fasting-like diet starves breast cancer cells, rendering them more sensitive to chemotherapy and strengthening the immune system's ability to fight the tumor, according to results of a study, “Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity,” published this month in the journal Cancer Cell. Current treatments for cancer, including radiotherapy and chemotherapy, normally hamper immune cells' efforts to kill a cancer. Short-term starvation has been shown to sensitize cancer cells to chemotherapeutics, while protecting normal cells from these drugs' side effects. Researchers in this study developed a fasting-mimicking diet — low in calories, protein, and sugar — and fed it to mice models of breast cancer. On average, animals fed a normal diet consumed 14.9 kcal per day. Animals under a fasting diet had that caloric total reduced by 50 percent on the first day, and were given only 9.7 percent on the following three days. These mice ate all the supplied food each day, and showed no signs of food aversion. After four days, the mice were fed normally for 10 days before starting another fasting-diet cycle. Interestingly, this diet plan was seen to reduce breast cancer cell growth in the absence of chemotherapy. Moreover, it sensitized cancer cells to the chemotherapy drugs doxorubicin (DXR) and cyclophosphamide (CP). Similar effects of the fasting-like diet were observed in a melanoma model, where a strict diet combined with those two chemo drugs resulted in a th
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.