Why Women Need To Know About PALB2 & Breast Cancer Risk

Why Women Need To Know About PALB2 & Breast Cancer Risk
PALB2 breast cancer geneA recent study has shown that women who are found to have mutations in the gene known as PALB2 are also likely to have a 1 in 3 chance of being diagnosed with breast cancer by the time they reach the age of 70. The study, “Breast-Cancer Risk in Families with Mutations in PALB2” was published in the New England Journal of Medicine and carried out by researchers from 17 research centers in 8 different countries, with scientists from the University of Cambridge in England leading the project. Through data obtained through the international PALB2 Interest Group, the investigators analyzed data from 154 families without BRCA1 or BRCA2 mutations, the most common mutations found in breast cancer cells, discovering that 362 family members carried deleterious truncating, splice mutations, or deletion mutations in the PALB2 gene. PALB2 interacts with BRCA1 and BRCA2, and women who are found to carry mutations within this gene and were born more recently have an increased risk of eventually developing breast cancer than women who were born earlier, a curious yet still unexplained fact that could be rel
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One comment

  1. Dora says:

    Does this gene skip a generation?
    If I am not positive for PALB2 and several of my siblings and mother are, will my children still need to be tested?

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