Study Finds microRNA-199a And FOXP2 Contribute to Breast Cancer Metastasis

Study Finds microRNA-199a And FOXP2 Contribute to Breast Cancer Metastasis
shutterstock_154017506By silencing the gene normally associated with speech regulation and language development, a group of researchers at Beth Israel Deaconess Medical Center (BIDMC) enhanced breast cancer cell metastasis, suggesting a previously unknown connection between the FOXP2 transcription factor and breast cancer cell survival. "We have identified a previously undescribed function for the transcription factor FOXP2 in breast cancer," said Antoine Karnoub, PhD, senior investigator of the article published in Cell Stem Cell, "MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis," in a news release from BIDMC. "We have found that depressed FOXP2 and elevated levels of its upstream inhibitor microRNA 199a are prominent features of clinically advanced breast cancers that associate with poor patient survival." At the heart of the study are mesenchymal stem cells (MSCs). MSCs produce a variety of factors that influence other cells' behavior. Dr. Karnoub's laboratory works with MSCs in th
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