Pathway Responsible For Breast Cancer Metastasis Identified By MD Anderson Researchers

Pathway Responsible For Breast Cancer Metastasis Identified By MD Anderson Researchers
Scientists at The University of Texas MD Anderson Cancer Center have discovered a signalling pathway responsible for breast cancer metastasis. The study, led by Liuqing Yang, Ph.D., assistant professor of molecular and cellular oncology, was published in this month's issue of Cell Molecules called long non-coding RNAs (lncRNAs) are known because of their role in metastasis and tumor growth. However, until now, the dimensions of that implication remained hidden under the complexity of the process. The group of researchers reported that hedgehog, a unique cell signalling pathway known to contribute towards many types of cancer, may be the one responsible for breast cancer metastasis. This pathway is a type of molecular message service that works with a lncRNA known as BCAR4, and gives the genetic permission for tumors to grow. “Our study of BCAR4 and the hedgehog signaling pathway has provided evidence for lncRNAs’ regulator roles in aggressive breast cancers progression. Emerging evidence has revealed lncRNAs as a new class of players in the development and progression of cancer", Dr. Yang said in a MD Anderson news release
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