Breast Cancer Survival Linked to Expression of 2 Genes

Breast Cancer Survival Linked to Expression of 2 Genes
Scientists at The Institute of Cancer Research in London have tested the activity of two genes that could predict an increased risk of mortality for women with breast cancers. The study titled “Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer, was published in the journal Oncotarget. Researchers analyzed nearly 2,000 patients whose breast cancer cells were positive for HER2, a protein found in almost 20 percent of breast cancer tumors. They found that women whose breast tumors had a particular pattern of activity in two specific genes were three times more likely to experience very poor prognosis within 10 years compared to others with a different pattern of activity in the same genes. The researchers discovered the negative pattern of gene activity among breast cancer cells that had a specific skill for escaping from the glue that usually holds them in place - known as the extracellular matrix (ECM). The team believes the two genes could play a key role in releasing cells from the ECM so they can more easily spread around the body. Researchers led by Dr Paul Huang, leader of the Protein Networks Team at The Institute of Cancer Research in London, developed an image-based screening test to detect breast cancer cells
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