Study Identifies Mechanism Regulating Breast Cancer Aggressiveness

Study Identifies Mechanism Regulating Breast Cancer Aggressiveness
A new study has offered insights into the exact mechanism breast cancer cells undergo in order to become aggressive. The findings, included in the study “Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma,” and published in the journal Antioxidants & Redox Signaling, show that the switch to these cells becoming more invasive can be traced all the way back to increased intracellular levels of an enzyme called manganese superoxide dismutase (MnSOD), which is an important regulator of the cells’ metabolic redox processes. The study was conducted by Alan Prem Kumar, MD, professor Shazib Pervaiz, MD, PhD, and associate professor Marie-Veronique Clement, PhD, as part of a collaboration between the Cancer Science Institute of Singapore at the National University of Singapore (NUS) and NUS Yong Loo Lin School of Medicine. The researchers had previously found that MnSOD levels were particularly higher in triple negative breast cancer cells, a particularly invasive breast cancer subtype with enhanced metastatic capabilities, compared to non-invasive or non-tumorigenic cells. Based on those findings, the team sought to determine the relationship between the intracellular metabolic environment and the tumor's ability to turn aggressive. "Our group's work over the years has highlighted the critical role of cancer cells' oxidative metabolism
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