Keytruda Helped Patients with Metastatic Triple-Negative Breast Cancer, Studies Find

Keytruda Helped Patients with Metastatic Triple-Negative Breast Cancer, Studies Find
Keytruda (pembrolizumab) was effective in treating triple-negative breast cancer regardless of whether women had received previous treatment, according to data presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. The studies, “Phase 2 study of pembrolizumab (pembro) monotherapy for previously treated metastatic triple-negative breast cancer (mTNBC): KEYNOTE-086 cohort A,” and “Phase 2 study of pembrolizumab as first-line therapy for PD-L1–positive metastatic triple-negative breast cancer (mTNBC): Preliminary data from KEYNOTE-086 cohort B,” were presented by researchers from the NYU Langone's Perlmutter Cancer Center. The trial (NCT02447003) included two groups of patients with advanced breast cancer that had spread to other locations. The first group was composed of 170 patients who had received extensive earlier treatment. Keytruda is a checkpoint-blocking drug, and patients in the first group were included regardless of whether the checkpoint molecule PD-L1 was present in the tumor. The second group had not received earlier treatment and had tumors expressing PD-L1. Among pre-treated patients, Keytruda shrank tumors by more than 30 percent in eight (5 percent) of the women, and stabilized disease in 35 women (21 percent) of the group. All eight patients who saw their tumors shrink lived for at least another
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  1. Judy bergbower says:

    I was thrilled to death to see this article. I have been on a study with keytruda for almost 2 years now. The amazing thing is my cancer is in the material cancer. My tumors are still shrinking and some have completely disappeared. I have often wondered lately if there is a way that I can find out how the study I am on is doing. I believe I’m on a study with 26 other women. I would really love to hear back from you if at all possible. I feel great and have no side effects at all from the keytruda. Any information you have regarding this immune therapy on endometrial cancer would certainly be appreciated

    • Magdalena Kegel says:

      Hi Judy,
      I am very happy to hear that Keytruda seems to be working for you. Unfortunately, however, I am sorry to say that I don’t have access to information outside of what we publish here. We at Breastcancer News rely on published and public sources for our reporting, and are not involved in research.

      There are several studies exploring Keytrud in women with endometrial cancer. Please check back here, and also at the website to learn of more data as it becomes available.

  2. Anne pokrefky says:

    I am on abraxane horrible chemo. I am t-negative metzed breast cancer to my bones. I wish I was on this. Chemo third time is ruining my life! 8(

  3. K.G says:

    I am 41 years old and have tripple negative breast cancer that has matasizied to the liver, bones, and now recently brain. I was able to get localized brain radiation. I was on different chemos for a year that evidently have not been successful. I will be starting Keytruda soon. I am very optimistic that this medication will work. I look forward in reading more success stories as well as telling my own

    • Dhvani says:

      Hi K.G.

      How you been doing ? I am also going through TNB and now dr suspected something in my lungs but they are not sure at this point .

      Can you give me your contact no ?


  4. Stephanie says:

    I’m 39 with Tneg, Mets to clavicle area. I’ve been in a Keytruda, gezmar and carbon trial since March. My tumors have shrunk over 50%. My oncologist is very pleased. It’s worth trying! Even if it just stabalizes the disease. Prayers to my mets sister’s.

    • Eucharia says:

      Where can I go to get treatment with keytrda? I am a 56 year ole woman with triple negative breast cancer that has metastasized to my bone. I am scheduled for second chem, this is troubling for me judging from my past experience with chemo.
      Please help.
      MRS. Eucharia. [email protected]. 4436573498.

    • Anna Everard says:

      Hi Stepanie! I am stage 4 triple negative as well and getting ready to go onto Gemzar, Carbo, and Keytruda clinical study. I am so pleased to read your comment! I started out with Carbo/Taxol for six months, then dropped to just Taxol for the last six months, just had a pet scan and it showed the cancer was trying to rear its ugly head again (liver and lungs). I would love to talk with you more, can you Face book friend me, my name is Anna Everard. I would like to know more about how you are feeling and your story. Hope to hear from you soon!

      Thanks! Anna Everard

    • Leen says:

      Hi Stephanie,

      I started your regime in Dec. 2018- After my first treatment of Keytruda, Carbo/Germ (chemos) it started burning the cancer- I actually felt the burning sensation. I pray that this treatment put us in remission. Be Blessed!

  5. Shannon Mosca says:

    My mom was recently released from a Keyteuda clinical trial because she was in the chemotherapy group and her tumors have grown too big. Can Keytruda currently be given as treatment? Doesn’t seem to hurt, if all others are failing.

    • Magdalena Kegel says:

      Hi Shannon,
      Keytruda is not approved for breast cancer, but since it is approved for other cancer types, it is possible for her oncologist to use it off-label, should she/he believe your mother can benefit from the treatment.

    • Sondra says:

      We are in Boston at Dana Farber and my sister recently started the Keyteuda clinical trial. Her next pet scan will be on May 14th.

    • Alicja Socha says:

      There are study starting with new medicine CCR5 inhibitor , Leronlimab .
      Medicine so far used for other diseases in studies , in over 830 patients , some using for about 5 years not one serious side effects .
      In pre-clinical study over 98% reduction of metastasis…
      Maybe try and contact this company , because according to new law ” right to try ” you have a right to try any medicine.
      Get more information about it .
      Company — CytoDyne ( CYDY )read their website.
      Telephone to IR 630-707-8585

      And good luck to you all.

    • Jessica V says:

      Your Doctor can approach Merck (the maker) for compassionate care. I am Tneg with a local reoccurance to sternum and inner mammary node, after Xeloda at the same time as radiation my doctor has me on Keytruda as a preventative.

  6. Charlene says:


    I have stage 4, Triple Negative Breast Cancer, this is the 3rd time this has came back within 2 years.
    I started a clinical trial in Dec. 2018 of Keytruda, carbo/germ. My first week is all 3 drugs.. Then the following is carbo/germ(chemos), Unfortunately, my white blood count is always too low for me to continue the following week of the 2 Chemos. However, my first treatment was a burning sensation and I know this treatment works! I had a CT scan in Jan 2019 and my lymph nodes has regressed to normal size and most of the cancer has totally disappeared. My trial is for 2 years – and I pray that this treatment will put me in remission. I Thank God for researchers and doctors that are determined to find a cure/save us from this disease. Stay Blessed !

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